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Consistent with its known effects on the nitric oxidecGMP pathway. Viagra was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years.
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In the nonpregnant rat the AUC at this dose was about 20 times human AUC. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers").